
Pts stay alkalemic until end, acidemia is indicative of high morbidity.
Initially respiratory alkalosis from direct effects on respiratory center, then metabolic acidosis from ketones, salicylate, and lactate. The NCPE of this toxin can be confused with pneumonia. Vomiting (central and peripheral causes) and Gastritis. Hyperglycemia becomes hypoglycemia when can not keep up with demand. Burns off all glucose, so gluconeogenesis with ketonemia. Used as an aborted experiment for heat production, in cold soldiers in Russia, as well as fat burning tool.) Other agents that uncouple ox phos are dinitrophenol and pentrophenol. Uncouples oxidative phosphorylation giving lactic acidosis and hyperthermia (the uncoupling, rather than blocking leads to heat production. Hyperventilation from direct effects on the respiratory center.
1.4 g per cc in pure form, less in Bengay (also can be absorbed topically) Acetylsalicylic Acid and Methyl Salicylate (Oil of Wintergreen) from willow bark.